Bioregulatory Peptides.
Mitochondrial-derived peptides and neuropeptide analogs for cellular homeostasis.
Peptide bioregulators participate in epigenetic modulation and mitochondrial metabolic homeostasis. The mitochondrial-derived peptide MOTS-c acts as an endocrine-like regulator of AMPK signaling, while regulatory neuropeptides Semax and Selank modulate BDNF neurotrophin expression.
AVAILABLE RESEARCH COMPOUNDS
PRECLINICAL PHARMACOLOGICAL ANALYSIS
Mitochondrial Homeostasis and Neurotrophin Signaling
MOTS-c targets the folate-methionine metabolic cycle, inducing AMPK phosphorylation independently of cellular AMP/ATP ratios. In neural systems, heptapeptides Semax and Selank modulate monoaminergic neurotransmission and stimulate brain-derived neurotrophic factor (BDNF) synthesis.
FREQUENTLY ASKED QUESTIONS
What is unique about MOTS-c?
MOTS-c is encoded within the mitochondrial genome (mtDNA) rather than nuclear DNA, functioning as an endocrine-like mitochondrial metabolic hormone.