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iberialabs
COMPOUND · MOT-051126102% FILL
mots-c 10 mg
Longevity
EXP: 05/2028

mots-c

mitochondrial-derived peptide

LOT:MOT-051126
CALCULATOR↗LAB REPORT (COA)↗
OUT OF STOCK0 VIALS AVAILABLE IN STOCK
100% EU Delivery Guarantee— free reshipment if lost
24h EU dispatch from Spain · Zero customs risk
HPLC certified purity >99% on every batch
FOR LABORATORY USE ONLY — NOT FOR HUMAN CONSUMPTION. SHIPS FROM THE EU WITHIN 24 H, EU DELIVERY 3-7 DAYS, SPAIN 1-3 DAYS.

what the literature shows.

A condensed monograph drawn from preclinical and clinical literature, cited mechanisms, specifications and the research case for mots-c.

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MOTS-c: Mitochondrial-Derived Peptide for Energy Homeostasis and Anti-Aging

MOTS-c is a naturally occurring mitochondrial-derived peptide that acts as a systemic metabolic regulator, promoting energy balance, cellular resilience, and longevity.

Structural Parameters of MOTS-c

PropertyValue and SpecificationReferences
CAS Number1627580-64-6
Molecular FormulaC101H152N28O22S2 (free base)
Molecular Weight2174.62 g/mol
Chemical ClassMitochondrial-derived peptide (MDP / mitokine)
SequenceMet-Arg-Trp-Gln-Glu-Met- Gly-Tyr-Ile-Phe-Tyr-Pro-Ar g-Lys-Leu-Arg

Origin, History, and Research Stage

MOTS-c was discovered in 2015 by Changhan Lee and Pinchas Cohen at the USC Davis School of Gerontology, establishing that mitochondria secrete active signaling peptides (mitokines). Because it significantly enhances exercise capacity and performance, the World Anti-Doping Agency (WADA) added MOTS-c to its prohibited list in 2024 under category S0. It remains an active area of pre-clinical study for metabolic health, skeletal muscle decline, and life extension.

Mechanism of Action and Pharmacokinetics

MOTS-c is a 16-amino acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S rRNA gene. It acts as a cytoprotector and nuclear transcriptor. Under metabolic stress, MOTS-c translocation to the cytosol and nucleus occurs, where it increases intracellular AICAR levels. This triggers the activation of AMP-activated protein kinase (AMPK). AMPK activation upregulates the GLUT4 glucose transporter, facilitating insulin-independent glucose uptake into skeletal muscle, and modulates folate/one-carbon metabolism to enhance stress adaptation.

Scientific and Clinical Effects

In vivo animal studies show that MOTS-c prevents weight gain in mice fed a high-fat diet, reverses age-induced insulin resistance, and restores glucose tolerance in older animals to youthful levels. Furthermore, it enhances physical performance, increases grip strength, and improves neuromuscular coordination, making it a promising candidate for counteracting sarcopenia and age-related physical decline.

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/ FREQUENTLY ASKED QUESTIONS & PROTOCOLS

Frequently asked questions about mots-c.

Technical reconstitution protocols, HPLC purity verification, storage conditions, and express European delivery details.

mots-c is brought into solution using the diluent specified on its technical datasheet: sterile bacteriostatic water or 0.9% NaCl. Insert the syringe and direct the stream gently against the inner vial wall. Swirl smoothly with circular motions rather than shaking vigorously, as mechanical agitation can shear delicate peptide chains. Once reconstituted, it remains stable refrigerated at 2–8 °C for up to 28 days.

At Iberia Labs, every batch of mots-c is verified by High-Performance Liquid Chromatography (HPLC) at ≥ 99.666% purity, with bacterial endotoxin levels strictly under 0.5 EU/mg and identity confirmed by Mass Spectrometry (MS). Each batch is backed by its lot-specific Certificate of Analysis (current lot: MOT-051126).

Lyophilized mots-c in vacuum-sealed vials should be stored at -20 °C, protected from light and moisture, with an unopened shelf life of 24 to 36 months. The sealed powder readily tolerates ambient temperature during transit without loss of potency. Upon receipt, transfer immediately to cold storage (-20 °C unopened, or 2–8 °C once reconstituted).

mots-c is available directly from Iberia Labs (iberialabs.eu), dispatched from warehouses within the European Union and Spain. Because shipments originate within the EU single market, orders are completely free from customs clearance delays. Orders dispatch within 24 hours, with 24–72 hour delivery in Spain and 2–5 business days across Europe.

Yes, mots-c may be legally purchased in Spain and throughout the European Union strictly for laboratory research, chemical analysis, and in-vitro or preclinical investigation (RUO). Iberia Labs supplies analytical-grade reagents exclusively to the scientific and research community. It is not an approved medicine and is not intended for human or animal consumption, nor for clinical diagnostics.

mots-c is available in individual vials (10 mg) starting at €39.95. Every order includes its verified lot-specific Certificate of Analysis at no extra cost. Prices are quoted in EUR and express shipping options are transparently calculated at checkout.

All confirmed orders of mots-c are dispatched within 24 business hours from our EU fulfillment facilities. Delivery across mainland Spain takes 24–72 hours via express courier. International European destinations arrive within 2–4 business days with secure and discreet packaging.

Yes. Every vial of mots-c is accompanied by an authentic Certificate of Analysis (CoA) for the current batch (MOT-051126). The report documents HPLC purity chromatograms, mass spectrometry identity validation, and endotoxin assays. You can view and download the full laboratory report directly in our Lab Report (CoA) section.