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iberialabs
COMPOUND · SEM-052326102% FILL
semaglutide 10 mg
Metabolic
EXP: 05/2028

semaglutide

Selective GLP-1 receptor agonist that optimizes glycemic regulation and incretin-driven metabolic satiety in research models.

LOT:SEM-052326
CALCULATOR↗LAB REPORT (COA)↗
01
IN STOCK · 7 VIALS AVAILABLE
100% EU Delivery Guarantee— free reshipment if lost
24h EU dispatch from Spain · Zero customs risk
HPLC certified purity >99% on every batch
FOR LABORATORY USE ONLY — NOT FOR HUMAN CONSUMPTION. SHIPS FROM THE EU WITHIN 24 H, EU DELIVERY 3-7 DAYS, SPAIN 1-3 DAYS.

what the literature shows.

A condensed monograph drawn from preclinical and clinical literature, cited mechanisms, specifications and the research case for semaglutide.

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Semaglutide: Long-Acting GLP-1 Receptor Agonist for Glycemic and Weight Regulation

Semaglutide is a modified incretin mimetic designed to provide exceptional stability, glycemic control, and appetite suppression for the management of diabetes and obesity.

Structural Parameters of Semaglutide

PropertyValue and SpecificationReferences
CAS Number910463-68-2 (free base); 910463-74-0 (sodium salt)
Molecular FormulaC187H291N45O59 (free base)
Molecular Weight4113.64 g/mol (free base)
Chemical Structure31-amino acid peptide, modified GLP-1 analog
Key ModificationsAib8 substitution and acylation at Lys26 with a C18 diacid4

Origin, History, and Research Stage

Semaglutide was developed by Novo Nordisk as a weekly alternative to once-daily Liraglutide, entering Phase 3 clinical evaluation under the SUSTAIN and STEP programs. The US FDA approved Semaglutide injection (Ozempic) in December 2017 for type 2 diabetes, an oral tablet (Rybelsus) in 2019, and a high-dose injection (Wegovy) for chronic weight management in June 2021. Its core patents extend protection through 2031–2033 in key markets.4

Mechanism of Action and Pharmacokinetics

Semaglutide acts as a selective agonist at the GLP-1 receptor (GLP-1R), sharing 94% structural homology with native GLP-1.4 Its long half-life is achieved through two modifications: ●​ Aib at Position 8: This non-coded amino acid substitution prevents cleavage by dipeptidyl peptidase-4 (DPP-4).4 ●​ Acylation at Lys26: A C18 fatty diacid (octadecanedioic acid) attached via a gamma-glutamyl linker enables high-affinity, reversible binding to human serum albumin.4 These modifications extend its half-life to approximately 165 hours (7 days), permitting once-weekly subcutaneous dosing.4 Semaglutide stimulates insulin secretion and suppresses glucagon release in a glucose-dependent manner 2, while delaying gastric emptying and acting centrally in the hypothalamus to increase satiety.

Scientific and Clinical Effects

In the STEP clinical trial program, once-weekly subcutaneous Semaglutide (2.4 mg) induced an average weight loss of 14.9% to 16% over 68 weeks, accompanied by improvements in blood pressure and lipid profiles. In the SELECT cardiovascular trial, Semaglutide demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in overweight or obese patients without diabetes.

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/ FREQUENTLY ASKED QUESTIONS & PROTOCOLS

Frequently asked questions about semaglutide.

Technical reconstitution protocols, HPLC purity verification, storage conditions, and express European delivery details.

semaglutide is brought into solution using the diluent specified on its technical datasheet: sterile bacteriostatic water or 0.9% NaCl. Insert the syringe and direct the stream gently against the inner vial wall. Swirl smoothly with circular motions rather than shaking vigorously, as mechanical agitation can shear delicate peptide chains. Once reconstituted, it remains stable refrigerated at 2–8 °C for up to 28 days.

At Iberia Labs, every batch of semaglutide is verified by High-Performance Liquid Chromatography (HPLC) at ≥ 99.875% purity, with bacterial endotoxin levels strictly under 0.5 EU/mg and identity confirmed by Mass Spectrometry (MS). Each batch is backed by its lot-specific Certificate of Analysis (current lot: SEM-052326).

Lyophilized semaglutide in vacuum-sealed vials should be stored at -20 °C, protected from light and moisture, with an unopened shelf life of 24 to 36 months. The sealed powder readily tolerates ambient temperature during transit without loss of potency. Upon receipt, transfer immediately to cold storage (-20 °C unopened, or 2–8 °C once reconstituted).

semaglutide is available directly from Iberia Labs (iberialabs.eu), dispatched from warehouses within the European Union and Spain. Because shipments originate within the EU single market, orders are completely free from customs clearance delays. Orders dispatch within 24 hours, with 24–72 hour delivery in Spain and 2–5 business days across Europe.

Yes, semaglutide may be legally purchased in Spain and throughout the European Union strictly for laboratory research, chemical analysis, and in-vitro or preclinical investigation (RUO). Iberia Labs supplies analytical-grade reagents exclusively to the scientific and research community. It is not an approved medicine and is not intended for human or animal consumption, nor for clinical diagnostics.

semaglutide is available in individual vials (10 mg) starting at €34.95. Every order includes its verified lot-specific Certificate of Analysis at no extra cost. Prices are quoted in EUR and express shipping options are transparently calculated at checkout.

All confirmed orders of semaglutide are dispatched within 24 business hours from our EU fulfillment facilities. Delivery across mainland Spain takes 24–72 hours via express courier. International European destinations arrive within 2–4 business days with secure and discreet packaging.

Yes. Every vial of semaglutide is accompanied by an authentic Certificate of Analysis (CoA) for the current batch (SEM-052326). The report documents HPLC purity chromatograms, mass spectrometry identity validation, and endotoxin assays. You can view and download the full laboratory report directly in our Lab Report (CoA) section.