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COMPOUND · 5-A-052426102% FILL
5-amino-1mq 10 mg
Longevity
EXP: 05/2028

5-amino-1mq

Blocks the NNMT enzyme to reverse cellular fat accumulation, resulting in optimized weight loss, accelerated energy metabolism, and enhanced body fat burning.

LOT:5-A-052426
CALCULATOR↗LAB REPORT (COA)↗
OUT OF STOCK0 VIALS AVAILABLE IN STOCK
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24h EU dispatch from Spain · Zero customs risk
HPLC certified purity >99% on every batch
FOR LABORATORY USE ONLY — NOT FOR HUMAN CONSUMPTION. SHIPS FROM THE EU WITHIN 24 H, EU DELIVERY 3-7 DAYS, SPAIN 1-3 DAYS.

what the literature shows.

A condensed monograph drawn from preclinical and clinical literature, cited mechanisms, specifications and the research case for 5-amino-1mq.

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5-Amino-1MQ: Selective NNMT Inhibitor for Metabolic Modulation and Cellular Regeneration

5-Amino-1MQ is a synthetic small-molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT), engineered to elevate intracellular NAD+ levels and combat age-associated metabolic decline.

Structural Parameters of 5-Amino-1MQ

PropertyValue and SpecificationReferences
CAS Number42464-96-0 (typically supplied as iodide salt)
Molecular FormulaC10H11IN2 (iodide salt); C10H11N2+ (active cation)
Molecular Weight286.11 g/mol (as iodide salt)
Chemical ClassSynthetic small-molecule quinolinium derivative
AppearanceRed-brown to dark brown solid powder

Origin, History, and Research Stage

5-Amino-1MQ was developed in 2018 by researchers at the University of Texas Medical Branch (UTMB). The molecule was identified through chemical screening designed to discover membrane-permeable compounds capable of blocking the substrate-binding site of NNMT. Currently, 5-Amino-1MQ is being investigated in pre-clinical studies for obesity, sarcopenia, and muscle stem cell senescence, and is increasingly utilized in anti-aging research.

Mechanism of Action and Pharmacokinetics

The active quinolinium cation of 5-Amino-1MQ selectively inhibits NNMT (IC50 = 1.2 microM). NNMT normally methylates nicotinamide (NAM) using SAM as a methyl donor, converting NAM into 1-MNA and removing it from the NAD+ synthesis pathway. By blocking NNMT, 5-Amino-1MQ prevents this depletion of NAM, redirecting it through the NAMPT salvage pathway to synthesize mononucleótido de nicotinamida (NMN) and subsequently NAD+. The resulting rise in cellular NAD+ activates SIRT1, which in turn upregulates AMPK and PGC-1alpha. This cascade triggers mitochondrial biogenesis and enhances cellular fatty acid oxidation.

Scientific and Clinical Effects

In diet-induced obesity (DIO) mouse models, oral or subcutaneous administration of 5-Amino-1MQ reverses weight gain, shrinks hypertrophic adipocytes, and reduces hepatic lipid accumulation without altering food intake. In aging and skeletal muscle models, 5-Amino-1MQ rejuvenates senescent muscle stem cells (satellite cells), increasing their regenerative capacity and supporting muscle tissue repair after injury.

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/ FREQUENTLY ASKED QUESTIONS & PROTOCOLS

Frequently asked questions about 5-amino-1mq.

Technical reconstitution protocols, HPLC purity verification, storage conditions, and express European delivery details.

5-amino-1mq is brought into solution using the diluent specified on its technical datasheet: sterile bacteriostatic water or 0.9% NaCl. Insert the syringe and direct the stream gently against the inner vial wall. Swirl smoothly with circular motions rather than shaking vigorously, as mechanical agitation can shear delicate peptide chains. Once reconstituted, it remains stable refrigerated at 2–8 °C for up to 28 days.

At Iberia Labs, every batch of 5-amino-1mq is verified by High-Performance Liquid Chromatography (HPLC) at ≥ 99.608% purity, with bacterial endotoxin levels strictly under 0.5 EU/mg and identity confirmed by Mass Spectrometry (MS). Each batch is backed by its lot-specific Certificate of Analysis (current lot: 5-A-052426).

Lyophilized 5-amino-1mq in vacuum-sealed vials should be stored at -20 °C, protected from light and moisture, with an unopened shelf life of 24 to 36 months. The sealed powder readily tolerates ambient temperature during transit without loss of potency. Upon receipt, transfer immediately to cold storage (-20 °C unopened, or 2–8 °C once reconstituted).

5-amino-1mq is available directly from Iberia Labs (iberialabs.eu), dispatched from warehouses within the European Union and Spain. Because shipments originate within the EU single market, orders are completely free from customs clearance delays. Orders dispatch within 24 hours, with 24–72 hour delivery in Spain and 2–5 business days across Europe.

Yes, 5-amino-1mq may be legally purchased in Spain and throughout the European Union strictly for laboratory research, chemical analysis, and in-vitro or preclinical investigation (RUO). Iberia Labs supplies analytical-grade reagents exclusively to the scientific and research community. It is not an approved medicine and is not intended for human or animal consumption, nor for clinical diagnostics.

5-amino-1mq is available in individual vials (10 mg) starting at €49.95. Every order includes its verified lot-specific Certificate of Analysis at no extra cost. Prices are quoted in EUR and express shipping options are transparently calculated at checkout.

All confirmed orders of 5-amino-1mq are dispatched within 24 business hours from our EU fulfillment facilities. Delivery across mainland Spain takes 24–72 hours via express courier. International European destinations arrive within 2–4 business days with secure and discreet packaging.

Yes. Every vial of 5-amino-1mq is accompanied by an authentic Certificate of Analysis (CoA) for the current batch (5-A-052426). The report documents HPLC purity chromatograms, mass spectrometry identity validation, and endotoxin assays. You can view and download the full laboratory report directly in our Lab Report (CoA) section.

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